Endocrine Abstracts

Water and electrolyte balance regulation plays a key role in essential hypertension pathogenesis. Indeed, alterations in kidney ability to excrete sodium and water in relation to intake have been proposed as a basic process of hypertension development. Vasopressin (AVP) acts through V2 receptors on the basolateral membrane of collecting duct principal cells to trigger the phosphorylation of Aquaporin 2 (AQP2) which moves from the cytoplasm to the apical membrane, making the ce...